Tuesday, September 13, 2016

Scientific Publication in Medical Biology - Monacord

Changing Trends of Unrelated Umbilical Cord Blood Transplantation for Hematologic Diseases in Patients Older than Fifty Years: A Eurocord-Center for International Blood and Marrow Transplant Research Survey

Over the last decade, there has been an increase in the use of umbilical cord blood (UCB) as an alternative source of stem cells both for children and adults. The development of double cord blood transplantation and the introduction of less toxic conditioning regimens helped to overcome the cell dose limitation and to decrease transplantation-related mortality, extending its use in adults. These advances in UCB transplantation (UCBT) techniques have resulted in acceptable outcomes for safety, engraftment, and survival, similar to those achieved with other graft sources. 

 

Nevertheless, in the last few years, we witnessed slower growth in the numbers of UCBTs and unrelated donor transplantations, which is likely related to the increasing use of haploidentical donors after the development of posttransplantation cyclophosphamide for graft-versus-host disease (GVHD) prophylaxis and unmanipulated graft.

 

In 2014, 2% of the allogeneic transplantations performed in Europe used UCB compared with 10% haploidentical and other mismatch siblings, 35% identical siblings, and 52% unrelated donor transplantations. Similar trends were reported by the Center for International Blood and Marrow Transplant Research (CIBMTR) [CIBMTR annual reports] with 8% UCBTs, 32% identical sibling, 11% haploidentical, and 50% unrelated donor transplantations.

Revue spécialisée "Biology of Blood and Marrow Transplantation" Volume 22

Rafii, H., Ruggeri, A., Volt, F., Brunstein, C.G., Carreras, J., Eapen, M., Gluckman, E. and Weisdorf, D.J. (2016) Changing Trends of Unrelated Umbilical Cord Blood Transplantation for Hematologic Diseases in Patients Older than Fifty Years: A Eurocord-Center for International Blood and Marrow Transplant Research Survey. Biol Blood Marrow Transplant.

 
 
For more information, see www.centrescientifique.mc or contact :

- Pr. Eliane Gluckman, Monacord Team Manager in the Scientific Centre of Monaco (egluckman@centrescientifique.mc).

 

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