Friday, April 28, 2017

Scientific Publication in Medical Biology Department - Monacord

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks.

Efforts to implement family cord blood banking have been developed in the past decades for siblings requiring stem cell transplantation for conditions such as sickle cell disease. However, public banks are faced with challenging decisions about the units to be stored, discarded, or used for other endeavors. We report here 20 years of experience in family cord blood banking for sickle cell disease in two dedicated public banks.

Participants were pregnant women who had previous child diagnosed with homozygous sickle cell disease. Participation was voluntary and free of charge. All mothers underwent mandatory serologic screening. Cord blood units were collected in different hospitals, but processed and stored in two public banks.

A total of 338 units were stored for 302 families. Median recipient’s age was 6 years (11 months –15 years). Median collected volume and total nucleated cell count were 91 ml (23–230) and 8.6 x108 (0.7–75 x108), respectively. Microbial contamination was observed in 3.5% (n=12), positive Hepatitis B serology in 25% (n=84) and homozygous sickle cell disease in 11% (n=37) of the collections. Forty-four units were HLA-identical to intended recipient, and 28 units were released for transplantation either alone (n=23) or in combination with the bone marrow from the same donor (n=5), reflecting a utilization rate of 8%. Engraftment rate was 96% with 100% survival.

Family cord blood banking yields good quality units for sibling transplantation. More comprehensive banking based on close collaboration among banks, clinical and transplant teams is recommended for optimized utilization of these units.

Rafii, H., Bernaudin, F., Rouard, H., Vanneaux, V., Ruggeri, A., Cavazzana, M., Gauthereau, V., Stanislas, A., Benkerrou, M., De Montalembert, M., Ferry, C., Girot, R., Arnaud, C., Kamdem, A., Gour, J., Touboul, C., Cras, A., Kuentz, M., Rieux, C., Volt, F., Cappelli, B., Maio, K.T., Paviglianiti, A., Kenzey, C., Larghero, J. and Gluckman, E. (2017) Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks. Haematologica Doi:10.3324/haematol.2016.163055.

 

 


 
For more information, see www.centrescientifique.mc or contact :

- Pr. Eliane Gluckman, Monacord Team Manager in the Scientific Centre of Monaco (egluckman@centrescientifique.mc).

- Dr Hanadi Rafii El Ayoubi (hanadi.rafii-elayoubi-ext@aphp.fr)
 
 

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