Tuesday, February 20, 2018

Award for the MONACORD group during the American Society of Hematology meeting.

Barbara Cappelli Lauro received the prize of “Abstract Achievement Awards” during the American Society of Hematology Meeting (ASH) that was held in Atlanta, Georgia, USA in December 2017 for the work entitled “Outcomes According to Age at Transplant with an HLA Identical Sibling for Sickle Cell Disease”. Moreover the work has been selected for the roadshow “2018 Highlights of ASH in North America”, where the world's leading hematology experts will present unbiased analyses of the most influential research presented at the latest ASH annual meeting.

The Monacord Group, headed by Professor Gluckman, has been studying Sickle cell disease and hematopoietic stem cell transplantation. Hematopoietic stem cell transplant (HSCT) from an HLA identical (HLAid) sibling donor is a well-established curative therapy for sickle cell disease (SCD). However, the ideal age to perform HSCT in SCD patients remains controversial. More than 700 HLAid sibling HSCTs performed throughout Europe were retrospectively analyzed. Patients were divided in three age groups: less than 5 years, 6-15 years and >15 years of age. Patients and transplants characteristics and outcomes were analyzed in the three groups. The study demonstrated that patients transplanted at a young age (less than 5 years) have a better 3-year Overall Survival (99%+1 vs 95%+1 vs 88%+3, p<0.001) as well as a better Event Free Survival (96%+2 vs 92%+1 vs 84%+4, p=0.001) with lower incidence of acute and chronic Graft versus host disease. These findings outline the importance of early referral to HSCT for SCD patients. Strategies to further evaluate pre HSCT, HSCT and donor factors that may influence survival and adverse outcomes could help improve HSCT results. 

© Monacord
Dr Barbara Cappelli, Monacord Team Researcher, received the prize of “Abstract Achievement Award” during the ASH, held in Atlanta, Georgia, USA in December 2017

For more information, see www.centrescientifique.mc or contact :

- Pr. Eliane Gluckman, Monacord Team Manager in the Scientific Centre of Monaco  (egluckman@centrescientifique.mc)

- Dr Barbara Cappelli LauroMonacord Team Researcher in the Scientific Centre of Monaco (bcappelli@centrescientifique.mc)
 

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