Wednesday, February 28, 2018

Dr. Jacques Pouysségur, invited to several international conferences

In these international meetings held in Vienna, Kyoto, Osaka and Ulsan, the research work of the CSM "Tumor Hypoxia and Metabolism" team was presented and discussed.

The 35th Altenberg Workshop in Theoretical Biology, "A Revised Theory of Cancer": 

This workshop was held in Vienna, Austria from 9 to 12 November 2017 and brought together some twenty international experts from different disciplines related to Cancer: Cell Biology, Genetics, Signalling, Metabolism, Mathematics, Cancer stem cells, Microenvironment, Immunology, Metastases, Philosophy... A large part of this unique meeting was dedicated to the discussion of several models of evolution / regression of cancers so as to bring out new theories restricting the dominating dogma of 'mutations' to make room for the impact of the tumor microenvironment.

Workshop participants "A revised Theory of Cancer", Vienna, 9-12 Nov. 2017, organized by Mina Bissel, Bernard Strauss, Ingemar Ernberg

J. Pouysségur, absent from the photo had to join Kyoto and present a conference at the invitation of Prof. Yoshinori Marunaka, President of the Physiological Society of Japan at the Kyoto Medical University.

© Univ. Kyoto
Kyoto Uniersity, Japon
© J. Pouysségur (CSM)
Botanical Garden Kyoto, November 2017


The 3rd International Symposium on "Currents Trends in Cancer and Signaling":

This symposium was held in Ulsan, South Korea from 23 to 26 November 2017 and brought together eighteen international experts from Asia, Europe, USA, Australia and covering different mechanisms of calcium, lipid, oncogenic signaling and new developments in miRNA and cancer research (Keynote Lecture by Carlo Croce) and mitotic entry mechanisms (Keynote Lecture by Tim Hunt, Nobel Prize in Medicine). All research presented and discussed at this meeting was published in late December in Advances in Biological Regulation.

Zdralevic M, Vucetic M, Daher B, Marchiq I, Parks S K and Pouysségur J. (2017). Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death. Adv Biol Regul pii: S2212-4926 (17): 30189-30196 

Our first results from the team on oxidative stress and pancreatic cancer, was presented at this meeting, project supported by the CSM and GEMLUC. Our first results of inactivation of the cystine transporter, essential for the synthesis of glutathione, major antioxidant, revealed a new form of lightning cell death called 'ferroptosis'. Our current research aims to explore the mechanisms of protection and induction of this cell death by playing on the redox status of cancers. We are seriously thinking about the future exploitation of a new anticancer therapeutic pathway.

Participants to the 3rd International Symposium on Currents Trends in Cancer and Signaling, Ulsan, South Korea, 23-26 Nov. 2017

 


Pour plus d’informations, consulter www.centrescientifique.mc ou contacter :

- Dr Jacques Pouysségur, Research Director Emeritus CNRS / CSM Team Leader of the 'Tumor Hypoxia and metabolism', Medical Biology Department, Centre Scientifique de Monaco (Jpouyssegur@centrescientifique.mc).

- Dr Milica VuceticPost-doctoral scientist in the 'Tumor Hypoxia and metabolism' team, Medical Biology Department, Centre Scientifique de Monaco (milica@centrescientifique.mc).

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