Bibliographie Biologie Médicale

2017

Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters
Tsuji T, Kurokawa Y, Chiche J, Pouyssegur J, Sato H, Fukuzawa H, Nagao M, Kambe T J Biol Chem 292(6): 2159-2173

Factors Associated with Long-Term Risk of Relapse after Unrelated Cord Blood Transplantation in Children with Acute Lymphoblastic Leukemia in Remission
Page K M, Labopin M, Ruggeri A, Michel G, Diaz de Heredia C, O'Brien T, Picardi A, Ayas M, Bittencourt H, Vora A J, Troy J, Bonfim C, Volt F, Gluckman E, Bader P, Kurtzberg J, Rocha V, Duke University, CBC-CTIWP, PDWP of EMBT, Eurocord Biol Blood Marrow Transplant 23(8): 1350-1358

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks
Rafii H, Bernaudin F, Rouard H, Vanneaux V, Ruggeri A, Cavazzana M, Gauthereau V, Stanislas A, Benkerrou M, De Montalembert M, Ferry C, Girot R, Arnaud C, Kamdem A, Gour J, Touboul C, Cras A, Kuentz M, Rieux C, Volt F, Cappelli B, Maio K T, Paviglianiti A, Kenzey C, Larghero J, Gluckman E Haematologica Doi:10.3324/haematol.2016.163055

Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells
Parks S, Cormerais Y, Durivault J, Pouyssegur J Oncotarget :1949-2553

Hypoxia and cellular metabolism in tumor pathophysiology
Parks S, Cormerais Y, Pouyssegur J J Physiologie 595(8): 2439-2450

Integration of a 'proton antenna' facilitates transport activity of the monocarboxylate transporter MCT4.
Noor S I, Pouyssegur J, Deitmer J W, Becker H M FEBS J 284(1): 149–162

Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients
Farge D, Arruda L C M, Brigant F, Clave E, Douay C, Marjanovic Z, Deligny C, Maki G, Gluckman E, Toubert A, Moins-Teisserenc H J Hematol Oncol 10: 21

Outcomes of UCB transplantation are comparable in FLT3+ AML: Results of CIBMTR, eurocord and EBMT collaborative analysis
Ustun C, Giannotti F, Zhang M-J, Wang H-L, Brunstein C, Labopin M, Rocha V, de Lima M, Baron F, Sandmaier B M, Eapen M, Gluckman E, Nagler A, Weisdorf D J, Ruggeri A Leukemia 31(6): 1408-1414

Single- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT
Baron F, Ruggeri A, Beohou E, Labopin M, Mohty M, Blaise D, Cornelissen J J, Chevallier P, Sanz G, Petersen E, Savani B N, Gluckman E, Nagler A J Hematol Oncol 10: 128

Sunitinib Stimulates Expression of VEGFC by Tumor Cells and Promotes Lymphangiogenesis in Clear Cell Renal Cell Carcinomas.
Dufies M, Giuliano S, Ambrosetti D, Claren A, Ndiaye P D, Mastri M, Moghrabi W, Cooley L S, Ettaiche M, Chamorey E, Parola J, Vial V, Lupu-Plesu M, Bernhard J C, Ravaud A, Borchiellini D, Ferrero J M, Bikfalvi A, Ebos J M, Khabar K S, Grépin R, Pagès G Cancer Res 77(5): 1212-1226

Targeting pH regulating proteins for cancer therapy-Progress and limitations
Parks S, Pouyssegur J Semin Cancer Biol 43: 66-73

The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and Human cells
Courtial L, Picco V, Grover R, Cormerais Y, Rottier C, Labbe A, Pagès G, Ferrier-Pagès C Scientific Reports 7: 45713

Umbilical Cord Blood Cytomegalovirus Serostatus Does Not Have an Impact on Outcomes of Umbilical Cord Blood Transplantation for Acute Leukaemia
Nikolajeva O, Rocha V, Danby R, Ruggeri A, Volt F, Baudoux E, Gomez S G, Kögler G, Larghero J, Lecchi L, Martinez M S, Navarrete C, Pouthiers F, Querol S, Kenzey C, Szydlo R, Gluckman E, Madrigal A Biologie Blood Marrow Transplant / doi: 10.1016/j.bbmt.2017.06.022

Validation of commercial ERK antibodies against the ERK orthologue of the scleractinian coral Stylophora pistillata
Courtial L, Picco V, Pagès G, Ferrier-Pagès C F1000Research 6(577)

2016

Changing Trends of Unrelated Umbilical Cord Blood Transplantation for Hematologic Diseases in Patients Older than Fifty Years: A Eurocord-Center for International Blood and Marrow Transplant Research Survey
Rafii H, Ruggeri A, Volt F, Brunstein C G, Carreras J, Eapen M, Gluckman E, Weisdorf D J Biol Blood Marrow Transplant 22(9): 1717-1720

Characterization of a Dmd (EGFP) reporter mouse as a tool to investigate dystrophin expression.
Petkova M V, Morales-Gonzales S, Relizani K, Gil E, Seifert F, Radke J, Stenzel W, Garcia L, Amthor H, Schuelke M Skelet Muscle: 6-25

ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?
Busca R, Pouyssegur J, Lenormand P Front Cell Dev Biol 4: 53

ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2
Picco V, Coste I, Giraud-Panis M-J, Renno T, Gilson E, Pagès G Oncotarget 7(29): 46615-46627

Genetic disruption of the multifunctional CD98/LAT1 complex demonstrates the key role of essential amino acid transport in the control of mTORC1 and tumor growth
Cormerais Y, Giuliano S, LeFloch R, Front B, Durivault J, Tambutté E, Massard P, Rodriguez de la Ballina L, Endou H, Wempe M F, Palacin M, Parks S, Pouyssegur J Cancer Research, doi: 10.1158/0008-5472.CAN-15-3376

Hypoxia in health and disease
Pouyssegur J, Lopez-Barneo J Mol Aspects Med 47-48: 1-2

Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export
Parks S, Cormerais Y, Marchiq I, Pouyssegur J Mol Aspects Med 47-48: 3-14

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
Marchiq I, Pouyssegur J J Mol Med 94 : 155-171

Hypoxia-dependent regulation of inflammatory pathways in immune cells
Taylor C, Doherty G, Fallon P G, Cummins E P J Clinical Investigation 126 (8):1-8

Impact of cord blood banking technologies on clinical outcome: a Eurocord/Cord Blood Committee (CTIWP), European Society for Blood and Marrow Transplantation and NetCord retrospective analysis
Saccardi R, Tucunduva L, Ruggeri A, Ionescu I, Koegler G, Querol S, Grazzini G, Lecchi L, Nanni Costa A, Navarrete C, Pouthiers F, Larghero J, Regan D, Freeman T, Bittencourt H, Kenzey C, Labopin M, Baudoux E, Rocha V, Gluckman E Transfusion 56(8): 2021-2029

Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation
Cunha R, Zago M A, Querol S, Volt F, Ruggeri A, Sanz G, Pouthier F, Kogler G, Vicario J L, Bergamaschi P, Saccardi R, Lamas C H, Diaz-de-Heredia C, Michel G, Bittencourt H, Tavella M, Panepucci R A, Fernandes F, Pavan J, Gluckman E, Rocha V Blood J, doi:10.1182/blood-2016-06-722249

Impact of HLA in cord blood transplantation outcomes
Ruggeri A, Paviglianiti A, Gluckman E, Rocha V HLA 87(6): 413-421

Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia.
Rocha V, Ruggeri A, Spellman S, Wang T, Sobecks R, Locatelli F, Askar M, Michel G, Arcese W, Iori AP, Purtill D, Danby R, Sanz GF, Gluckman E, Eapen M Biol Blood Marrow Transplant 22(7): 1284-1289

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Brand A, Singer K, Koehl G E, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner P J, Hoffmann P, Walenta S, Geissler E K, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M Cell Metab 24(5): 657-671

Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression.
Zakraoui O, Marcinkiewicz C, Aloui Z, Othman H, Grépin R, Haoues M, Essafi M, Srairi-Abid N, Gasmi A, Karoui H, Pagès G, Essafi-Benkhadir K Mol Carcinog 56(1): 18-35

Na+/H+ antiporter (NHE1) and lactate/H+ symporters (MCTs) in pH homeostasis and cancer metabolism
Counillon L, Bouret Y, Marchiq I, Pouyssegur J Biochim Biophys Ac 1863(10): 2465–2480

Outcomes after unrelated umbilical cord blood transplantation for children with osteopetrosis
Chiesa R, Ruggeri A, Paviglianiti A, Zecca M, Gonzalez-Vicent M, Bordon V, Stein J, Lawson S, Dupont S, Dini G, Abecasis M, Al-Seraihy A, Kenzey C, Bierings M, Locatelli F, Gluckman E, Schulz A, Gennery A, Page K, Kurtzberg J, Vanderson R Biol Blood Marrow Transplant 22(11): 1997-2002

Outcomes of unrelated cord blood transplantation in patients with multiple myeloma: a survey on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobiology Working Party, and the Chronic Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Paviglianiti A, Xavier E, Ruggeri A, Ceballos P, Deconinck E, Cornelissen J J, Nguyen-Quoc S, Maillard N, Sanz G, Rohrlich P-S, Garderet L, Volt F, Rocha V, Kroeger N, Gluckman E, Fegueux N, Mohty M Haematologica 101(9): 1120-1127

Reorganization of Respiratory Descending Pathways following Cervical Spinal Partial Section Investigated by Transcranial Magnetic Stimulation in the Rat
Vinit S, Keomani E, Deramaudt T, Bonay M, Petitjean M Plos One 11(2): e0148180

RIC versus MAC UCBT in adults with AML: A report from Eurocord, the ALWP and the CTIWP of the EBMT.
Baron F, Ruggeri A, Beohou E, Labopin M, Sanz G, Milpied N, Michallet M, Bacigalupo A, Blaise D, Sierra J, Socie G, Cornelissen J J, Schmid C, Giebel S, Gorin N C, Esteve J, Ciceri F, Savani B N, Mohty M, Gluckman E, Nagler A Oncotarget 7(28): 43027-43038

Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation
Gluckman E, Cappelli B, Bernaudin F, Labopin M, Volt F, Carreras J, Simoes B P, Ferster A, Dupont S, de la Fuente J, Dalle J-H, Zecca M, Walters M C, Krishnamurti L, Bhatia M, Leung K, Yanik G, Kurtzberg J, Dhedin N, Kuentz M, Michel G, Apperley J, Lutz P, Neven B, Bertrand Y, Vannier J P, Ayas M, Cavazzana M, Matthes-Martin S, Rocha V, Elayoubi H, Kenzey C, Bader P, Locatelli F, Ruggeri A, Eapen M Blood, doi.org/10.1182/blood-2016-10-745711

Systematic analysis of AU-rich element expression in cancer reveals common functional clusters regulated by key RNA-binding proteins.
Hitti E, Bakheet T, Al-Souhibani N, Moghrabi S, Al-Yahya S, Al-Ghamdi M, Al-Saif M, Shoukri M M, Lanczk A, Grépin R, Gyorffy B, Pagès G, Khabar K S Cancer Res 76(14): 4068-4080

Telomeric repeat-binding factor 2: a marker for survival and anti-EGFR efficacy in oral carcinoma
Benhamou Y, Picco V, Raybaud H, Sudaka A, Chamorey E, Brolih S, Monteverde M, Merlano M, Nigro C L, Ambrosetti D, Pagès G Oncotarget 7: 44236-44251

The hypoxia-inducible factor (HIF) couples immunity with metabolism.
Halligan D N, Murphy S J, Taylor C Semin Immunol 16: 30097-30095

The telomere proteins in tumorigenesis and clinical outcomes of oral squamous cell carcinoma
Benhamou Y, Picco V, Pagès G Oral Oncol 57: 46-53

Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides
Goyenvalle A, Leumann C, Garcia L J Neuromuscul Dis 3(2): 157-167

Unrelated cord blood transplantation for acute leukemia diagnosed in the first year of life: outcomes and risk factor analysis
Ruggeri A, Volt F, Locatelli F, Michel G, de Heredia C D, Abecasis M, Zecca M, Vora A, Yakouben K, O'Brien T A, Giardino S, Cornish J, Rocha V, Peters C, Bader P, Gluckman E, Dalle J H Biol Blood Marrow Transplant 23(1): 96-102

Unrelated cord blood transplantation for childhood acute myelogenous leukemia: The influence of cytogenetic risk group stratification.
Michel G, Cunha R, Ruggeri A, O'Brien T A, Bittencourt H, Dalle J H, Locatelli F, Iori A P, Mauad M, Oudin C, Giannotti F, Volt F, Gluckman E, Bader P, Rocha V Leukemia 30(5): 1180-1183

Unrelated Cord Blood Transplantation in adults: evolution, experience and long-term outcomes in the UK National Health Service : a retrospective analysis on behalf of the British Society of Blood and Marrow Transplantation and Eurocord
Snowden J A, Danby R, Ruggeri A, Marks D I, Hough R E, Pagliuca A, Potter M, Russell N, Craddock C, Clark A, Miller P, Cook G, Gluckman E, Shaw B E, Rocha V Br J Haematol 172(3): 478-481

2015

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of ras-transformed fibroblasts
Pelletier J, Roux D, Viollet B, Mazure NM, Pouyssegur J Oncotarget 6(14): 11833-11847

Caspase-independent apoptosis in infected macrophages triggered by sulforaphane via Nrf2/p38 signaling pathways.
Bonay M, Roux A L, Floquet J, Retory Y, Herrmann J L, Lofaso F, Deramaudt T Cell Death Discov 1: 15022

Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia
Ruggeri A, Labopin M, Sanz G, Piemontese S, Arcese W, Bacigalupo A, Blaise D, Bosi A, Huang H, Karakasis D, Koc Y, Michallet M, Picardi A, Sanz J, Santarone S, Sengelov H, Sierra J, Vincent L, Volt F, Nagler A, Gluckman E, Ciceri F, Rocha V, Mohty M Leukemia 29(9): 1891-1900

Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status
Granja S, Marchiq I, Le Floch R, Moura C S, Baltazar F, Pouyssegur J Oncotarget 6(9): 6708-6721

Dysferlin rescue by spliceosome-mediated pre-mRNA trans-splicing targeting introns harbouring weakly defined 3' splice sites
Philippi S, Lorain S, Beley C, Peccate C, Precigout G, Spuler S, Garcia L Hum Mol Genet 24(14): 4049-4060

ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1
Busca R, Christen R, Lovern M, Clifford A M, Yue J X, Goss G G, Pouyssegur J, Lenormand P BMC Evol Biol 15(1): 179

Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers
Goyenvalle A, Griffith G, Babbs A, Andaloussi S E, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Voit T, Amthor H, Buhr C, Schurch S, Wood M J A, Davies K E, Vaillend C, Leumann C, Garcia L Nat Med 21(3): 270-275

Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin
Marchiq I, Le Floch R, Roux D, Simon M P, Pouyssegur J Cancer Res 75(1): 171-180

In vivo dynamics of skeletal muscle Dystrophin in zebrafish embryos revealed by improved FRAP analysis.
Bajanca F, Gonzalez-Perez V, Gillespie S J, Beley C, Garcia L, Theveneau E, Sear R P, Hughes S M Elife 4

Influence of glutathione S-transferase gene polymorphisms on busulfan pharmacokinetics and outcome of hematopoietic stem-cell transplantation in thalassemia pediatric patients
Ansari M, Huezo-Diaz P, Rezgui M A, Marktel S, Duval M, Bittencourt H, Cappelli B, Krajinovic M Bone Marrow Transplant 51(3): 377 -383

Knock out of the BASIGIN/CD147 chaperone of Lactate/H+ symporters disproves its pro-tumour action via Extracellular Matrix Metalloproteases (MMPs) induction.
Marchiq I, Albrengues J, Granja S, Gaggioli C, Pouyssegur J, Simon MP Oncotarget 6(28): 24636-24648

Knockout of Vdac1 activates HIF through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation
Brahimi-Horn CM, Giuliano S, Saland E, Lacas-Gervais S, Sheiko T, Pelletier J, Bourget I, Bost F, Féral C, Boulter E, Tauc M, Ivan M, Garmy-Susini B, Popa A, Mari B, Sarry JE, Craigen WJ, Pouyssegur J, Mazure NM Cancer Metab 3: 8

Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia
Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouyssegur J, Mazure NM Mol Cell Biol 35(9): 1491-1505

Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect
Compan V, Pierredon S, Vanderperre B, Krznar P, Marchiq I, Zamboni N, Pouyssegur J, Martinou J-C Mol Cell 59(3): 491-501

Nrf2: new insight in cell apoptosis
Bonay M, Deramaudt T Cell Death Dis 6: e1897

Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux
Giuliano S, Cormerais Y, Dufies M, Grépin R, Colosetti P, Belaid A, Parola J, Martin A, Lacas-Gervais S, Mazure N M, Benhida R, Auberger P, Mograbi B, Pagès G Autophagy 11(10): 1891-1904

The Na+/HCO3- co-transporter SLC4A4 plays a role in growth and migration of colon and breast cancer cells.
Parks S, Pouyssegur J J Cell Physiol 230(8): 1954-1963

The Saccharomyces boulardii CNCM I-745 Strain Shows Protective Effects against the B. anthracis LT Toxin
Pontier-Bres R, Rampal P, Peyron J F, Munro P, Lemichez E, Czerucka D Toxins 7(11): 4455-4467

Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice
Yufune S, Satoh Y, Takamatsu I, Ohta H, Kobayashi Y, Takaenoki Y, Pagès G, Pouyssegur J, Endo S, Kazama T Sci Rep 5: 10252

Un nouvel outil pour le traitement de la myopathie de Duchenne : les tricyclo-ADN
Goyenvalle A, Griffith G, Avril A, Amthor H, Garcia L Med Sci 31(3): 253-256

Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood-a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation.
Baron F, Labopin M, Ruggeri A, Mohty M, Sanz G, Milpied N, Bacigalupo A, Rambaldi A, Bonifazi F, Bosi A, Sierra J, Yakoub-Agha I, Santasusana JM, Gluckman E, Nagler A J Hematol Oncol 8(1): 107

2014

Conventional techniques to monitor mitochondrial oxygen consumption
Simonnet H, Vigneron A, Pouyssegur J Methods Enzymol 542: 151-161

Engraftment kinetics and graft failure after single umbilical cord blood transplantation using myeloablative conditioning regimen
Ruggeri A, Labopin M, Sormani MP, Sanz G, Sanz J, Volt F, Michel G, Locatelli F, Diaz De Heredia C, O' Brien T, Arcese W, Iori AP, Querol S, Kogler G, Lecchi L, Pouthier F, Garnier F, Navarrete C, Baudoux E, Fernandes J, Kenzey C, Eapen M, Gluckman E, Rocha V, Saccardi R Haematologica 99(9): 1509-1515

Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome
Doyen J, Trastour C, Ettore F, Peyrottes I, Toussant N, Gal J, Ilc K, Roux D, Parks S, Ferrero J M, Pouyssegur J Biochem Biophys Res Commun 451(1): 54-61

HIF-prolyl hydroxylase 2 inhibition enhances the efficiency of mesenchymal stem cell-based therapies for the treatment of critical limb ischemia
HoWangYin KY, Loinard C, Bakker W, Guérin CL, Vilar J, D'Audigier C, Mauge L, Bruneval P, Emmerich J, Lévy BL, Pouyssegur J, Smadja DM, Silvestre JS Stem Cells 32(1): 231-243

Interdisciplinary approaches of transcranial magnetic stimulation applied to a respiratory neuronal circuitry model
Vinit S, Keomani E, Deramaudt T, Spruance V M, Bezdudnaya T, Lane M A, Bonay M, Petitjean M Plos One 9(11): e113251

Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle.
Mouisel E, Relizani K, Mille-Hamard L, Denis R, Hourdé C, Agbulut O, Patel K, Arandel L, Morales-Gonzalez S, Vignaud A, Garcia L, Ferry A, Luquet S, Billat V, Ventura-Clapier R, Schuelke M, Amthor H Am J Physiol Regul Integr Comp Physiol 307(4): R444-454

Saccharomyces boulardii modifies Salmonella typhimurium traffic and host immune responses along the intestinal tract
Pontier-Bres R, Munro P, Boyer L, Anty R, Imbert V, Terciolo C, Andre F, Rampal P, Lemichez E, Peyron J-F, Czerucka D PLoS One 9(8): e103069

Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
Pettersen E O, Ebbesen P, Gieling R G, Williams K J, Dubois L, Lambin P, Ward C, Meehan J, Kunkler I H, Langdon S P, Ree A H, Flatmark K, Lyng H, Calzada M J, Peso L D, Landazuri M O, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton D C, Haider S, Buffa F M, Harris A L, Scozzafava A, Supuran C T, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop K M, Wouters B G, Koritzinsky M, Mujcic H, Cojocari D J Enzyme Inhib Med Chem 27: 1-33

The CXCL7/CXCR1/2 Axis Is a Key Driver in the Growth of Clear Cell Renal Cell Carcinoma.
Grépin R, Guyot M, Giuliano S, Boncompagni M, Ambrosetti D, Chamorey E, Scoazec JY, Negrier S, Simonnet H, Pagès G Cancer Res 74(3): 873-883

The ELR+CXCL chemokines and their receptors CXCR1/CXCR2: A signaling axis and new target for the treatment of renal cell carcinoma.
Giuliano S, Guyot M, Grépin R, Pagès G Oncoimmunology 3: e28399

The relevance of testing the efficacy of anti-angiogenesis treatments on cells derived from primary tumors: a new method for the personalized treatment of renal cell carcinoma.
Grépin R, Ambrosetti D, Marsaud A, Gastaud L, Amiel J, Pedeutour F, Pagès G, Plos One 9(3): e89449

Unrelated Cord Blood Transplantation for Patients with Primary or Secondary Myelofibrosis.
Robin M, Giannotti F, Deconinck E, Mohty M, Michallet M, Sanz G, Chevallier P, Cahn JY, Legrand F, Rovira M, Passweg J, Sierra J, Nguyen S, Maillard N, Yakoub-Agha I, Linkesch W, Cannell P, Marcatti M, Bay JO, Chalandon Y, Kröger N, Gluckman E, Rocha V, Olavarria E, Ruggeri A Biol Blood Marrow Transplant 20(11): 1841-1846

2013

Disrupting proton dynamics and energy metabolism for cancer therapy.
Parks S, Chiche J, Pouyssegur J Nat Rev Cancer 3 (9): 611-623

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels
Parks S, Mazure NM, Counillon L, Pouyssegur J J Cell Physiol 228: 1854-1862

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radio-sensitizes tumor cells by increasing intracellular acidosis
Doyen J, Parks S, Marcié S, Pouyssegur J, Chiche J Front Oncol 2(199): 1-10

Linking JNK Activity to the DNA Damage Response
Picco V, Pagès G Genes & Cancer 4(9-10): 360-368

Quantitative in-vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis.
Lutz NW, Le Fur Y, Chiche J, Pouyssegur J, Cozzone PJ Cancer Res 73: 4616-4628

Tumor hypoxia and metabolism - Towards novel anticancer approaches.
Chiche J, Ricci JE, Pouyssegur J Ann Endocrinol 74(2): 111-114