Monacord
Composition de l'équipe
Directeur de recherche
Chargé(e) de Recherche
Activités
Depuis 2012, grâce à un partenariat avec le Gouvernement de Monaco et soutenu par SAS le Prince Albert II, l’Association Eurocord Paris a bénéficié d’une convention avec le Centre Scientifique de Monaco, permettant ainsi la gestion de l’Observatoire International sur la Drépanocytose: Monacord.
La Drépanocytose est une maladie héréditaire sévère de l’hémoglobine atteignant surtout les personnes d’origine de régions d'Afrique subsaharienne, d'Inde, du Moyen-Orient et du bassin méditerranéen. En raison de la récente migration mondiale de la population, la drépanocytose est désormais un problème de santé dans nombreuses régions bien au-delà de ses origines géographiques. Cette maladie génétique est reconnue comme un problème global de santé publique depuis 2005 par de nombreuse organisations internationales (Union Africaine; UNESCO; WHO; Nations Unies), d’où l’importance du travail de recherche réalisé dans le cadre du projet Monacord soutenu par le gouvernement monégasque.
Les patients drépanocytaires présentent des symptômes notamment anémie, crises vaso-occlusives et accidents vasculaires cérébraux qui causent une mauvaise qualité de vie et une espérance de vie réduite. Le seul traitement curatif est la greffe de cellules souches hématopoïétiques.
Dans ce cadre, Monacord a établi des relations internationales entre pays développés et pays émergents afin de mettre en place des études épidémiologiques, de développer des méthodes de diagnostic et d’établir des protocoles de recherche pour le traitement de cette maladie.
Parmi les objectifs atteints, Monacord a obtenu des importantes reconnaissances internationales avec des études scientifiques sur :
- la greffe des cellules souches à partir de la fratrie HLA-identique comme traitement curatif définitif de la Drépanocytose ;
- des nouveaux traitements des femmes enceintes atteintes de la Drépanocytose et les nouveaux nés.
Dans les futurs projets, Monacord va s’occuper de :
- la formulation des recommandations cliniques pour la prise en charge de la drépanocytose, y compris les indications pour la greffe de cellules souches hématopoïétiques ou les autres thérapies innovantes telles que la thérapie génique ;
- le développement et la coordination des actions en faveur du diagnostic et du traitement de la Drépanocytose ;
- la diffusion des connaissances sur ce sujet en particulier dans les pays africains ;
- l’identification des centres pour le développement d’essais thérapeutiques adaptés aux ressources locales ;
- la réalisation des études de coût-efficacité et optimisation du traitement basé sur les ressources des pays.
Pour réaliser ses objectifs, Monacord travaille en étroite collaboration avec :
- Eurocord-Paris, Hôpital Saint Louis, Paris (France),
- Registres internationaux :
– EBMT (European Bone Marrow transplant group),
– CIBMTR (Center for International Blood and Marrow Transplant Research,
– NIH (National Institute of Health). - Hôpital Bambino Gesù, Rome, Vatican, Italy,
- Université de Sao Paulo, Brasil,
- Cordons de Vie, Association Scientifique Monegasque (Monaco),
- Direction Coopération Internationale (DCI) (Monaco),
- Muhimbili University of Health and Allied Sciences, Tanzania (MUHAS),
- Autres organisations nationales et internationales.
Publications
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Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan
Watanabe M, Kanda J, Volt F, Ruggeri A, Suzuki R, Rafii H, Kimura F, Cappelli B, Kondo E, Scigliuolo G, Takahashi S, Kenzey C, Rivera-Franco M M, Okamoto S, Rocha V, Chevallier P, Sanz J, Fürst S, Cornelissen J, Milpied N, Uchida N, Sugio Y, Kimura T, Ichinohe T, Fukuda T, Mohty M, Peffault de Latour R, Atsuta Y, Gluckman E
Blood Advances 8(3):640-652 -
Long-Term Stability of Cord Blood Units After 29 Years of Cryopreservation: Follow-Up Data From the José Carreras Cord Blood Bank
Liedtke S, Többen S, Gressmann H, Meyer A, Verde P E, Gluckman E, Kogler G
stcltm 13(1):30-42 -
Umbilical Cord Blood Transplantation for Fanconi Anemia With a Special Focus on Late Complications: a Study on Behalf of Eurocord and SAAWP-EBMT
Rafii H, Volt F, Bierings M, Dalle J-H, Ayas M, Rihani R, Faraci M, de Simone G, Sengeloev H, Passweg J, Cavazzana M, Costello R, Maertens J, Biffi A, Johansson J-E, Montoro J, Roth Guepin G, Diaz M A, Sirvent A, Kenzey C, Rivera Franco M M, Cappelli B, Scigliuolo G, Rocha V, Ruggeri A, Risitano A, Perrault De Latour R, Gluckman E
Transplantation and Cellular Therapy 2024 May;30(5):532.e1-532.e16 -
Unsupervised Clustering Analysis of Regimen and HLA Characteristics in Pediatric Umbilical Cord Blood Transplantation
Rivera-Franco M M, Wynn L, Volt F, Hernandez D, Cappelli B, Scigliuolo G, Danby R, Horton R, Gibson D, Rafii H, Kenzey C, Rocha V, Ruggeri A, Tamouza R, Gluckman E
Transplantation and Cellular Therapy 2024 Sep;30(9):910.e1-910.e15
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Comparative analysis of the variability of the human leukocyte antigen peptide-binding pockets in patients with acute leukaemia
Boukouaci W, Rivera-Franco M M, Volt F, Wu C-L, Rafii H, Cappelli B, Scigliuolo G, Kenzey C, Ruggeri A, Rocha V, Gluckman E, Tamouza R
BJH 2023;200(2):197-209 -
HLA haplotype frequencies and diversity in patients with hemoglobinopathies
Scigliuolo G, Boukouaci W, Cappelli B, Volt F, Rivera Franco M M, Dhédin N, Peffault De Latour R, Devalck C, Dalle J-H, Castelle M, Hermine O, Ouachée Chardin M, Poiré X, Brichard B, Paillard C, Rafii H, Kenzey C, Wu C-L, Bouassida J, Robin M, Raus N, Rocha V, Ruggeri A, Gluckman E, Tamouza R, Eurocord and SFGM-TC
eJHaem 4(4):963-969 -
Impact of Allele-Level HLA-Matching on Outcomes after Double Cord Blood Transplantation in Adults with Malignancies
Fatobene G, Mariano L, Volt F, Moreira F, Conelissen J, Furst S, Daguindau E, Sirvent A, Peffault de Latour R, Rafii H, Rivera Franco M, Kenzey C, Scigliuolo G, Cappelli B, Ruggeri A, Gluckman E, Rocha V
Blood Advances ADV-2022-009251R1 -
Outcomes of graft failure after umbilical cord blood transplantation in acute leukemia: a study from Eurocord and the Acute Leukemia Working Party of the EBMT
Baron F, Ruggeri A, Peczynski C, Labopin M, Bourhis J H, Michallet M, Chevallier P, Sanz J, Forcade E, Saccardi R, Potter V, Gluckman E, Nagler A, Mohty M
Bone Marrow Transplant 58, 936-941 (2023) -
Outcomes of subsequent neoplasms after umbilical cord blood transplantation in Europe
Rafii H, Ruggeri A, Kenzey C, Sanz J, Peffault De La Tour R, Esquirol A, Michel G, Chevallier P, Rubio M T, Cornelissen J J, Michallet M, Volt F, Rivera-Franco M M, Scigliuolo G, Cappelli B, Rocha V, Gluckman E
Blood Advances 7(10):1976-1986 -
Unrelated Donor Cord Blood Transplantation in Children: Lessons Learned Over 3 Decades
Kurtzberg J, Troy J D, Page K M, Rafii El Ayoubi H, Volt F, Scigliuolo G, Cappelli B, Rocha V, Ruggeri A, Gluckman E
stcltm Volume 12, Issue 1, Pages 26–38 -
Use of Letermovir in Umbilical Cord Blood Transplantation Based on Risk Scores
Rivera Franco M, Rafii H, Volt F, Kenzey C, Cappelli B, Scigliuolo G, Rocha V, Raus N, Dalle J-H, Chevallier P, Robin M, Rubio M T, Ruggeri A, Gluckman E
Blood Advances 2023 Jun 5;bloodadvances.2023010573
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Comparison of Outcomes after Unrelated Double-Unit Cord Blood and Haploidentical Peripheral Blood Stem Cell Transplantation in Adults with Acute Myelogenous Leukemia: A Study on Behalf of Eurocord and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Ruggeri A, Galimard J-E, Labopin M, Rafii H, Blaise D, Ciceri F, Diez-Martin J-L, Cornelissen J, Chevallier P, Sanchez-Guijo F, Nicholson E, Castagna L, Forcade E, Kuball J, Rovira M, Koc Y, Pavlu J, Gulbas Z, Vydra J, Baron F, Sanz J, Spyridonidis A, Savani B, Gluckman E, Nagler A, Mohty M
Transplantation and Cellular Therapy 28(10):710.e1-710.e10 -
Impact of COVID-19 pandemic on the use and release of cord blood units facilitated by the French Cord Blood Banks Network: on behalf of the Agency of Biomedicine, Eurocord and the French Society of Bone Marrow Transplant and Cell Therapy (SFGM-TC)
Rafii H, Ionescu I, Ruggeri A, Garnier F, Ballot C, Bensoussan D, Chabannon C, Dazey B, De Vos J, Gautier E, Giraud C, Larghero J, Cras A, Mialou V, Persoons V, Pouthier F, Thibert J-B, Dalle J-H, Michel G, Sinayoko M, Kenzey C, Volt F, Rocha V, Bay J-O, Rubio M-T, Robin M, Faucher C, Marry E, Gluckman E
Bone Marrow Transplant 57(1):125-127 -
Outcomes of subsequent neoplasms after umbilical cord blood transplantation in Europe
Rafii H, Ruggeri A, Kenzey C, Sanz J, Peffault De La Tour R, Esquirol A, Michel G, Chevallier P, Rubio M-T, Cornelissen J J, Michallet M, Volt F, Rivera-Franco M M, Scigliuolo G, Cappelli B, Rocha V, Gluckman E
Blood Advances 2022 Nov 9, 2022007941 -
Possible effect of the use of mesenchymal stromal cells in the treatment of Autism Spectrum Disorders : A review
Tamouza R, Volt F, Richard J-R, Wu C-L, Bouassida J, Boukouaci W, Lansiaux P, Cappelli B, Scigliuolo G, Rafii H, Kenzey C, Mezouad E, Naamoune S, Chami L, Lejuste F, Farge D, Gluckman E
Front Cell Dev Biol 10.3389 -
The impact of GVHD on outcomes after adult single cord blood transplantation in European and Japanese populations
Kanda J, Hayashi H, Ruggeri A, Kimura F, Volt F, Takahashi S, Kako S, Tozatto-Maio K, Yanada M, Sanz G, Uchida N, Angelucci E, Kato S, Mohty M, Forcade E, Tanaka M, Sierra J, Ohta T, Saccardi R, Fukuda T, Ichinohe T, Kimura T, Rocha V, Okamoto S, Nagler A, Atsuta Y, Gluckman E
Bone Marrow Transplant 57(1): 57-64 -
Umbilical Cord Blood Transplantation after Graft Failure from a Previous Hematopoietic Stem Cell Transplantation
Volt F, Ruggeri A, Scigliuolo G, Peffault de Latour R, Bierings M, Al-Seraihy A, Bittencourt H, Labussière-Wallet H, Rocha V, Kenzey C, Cappelli B, Rafii H, Gluckman E, Guerino-Cunha R L
Transplantation and Cellular Therapy Vol.28, pp.46.e1-46.e7 -
Upfront Alternative Donor Transplant versus Immunosuppressive Therapy in Patients with Severe Aplastic Anemia Who Lack a Fully HLA-Matched Related Donor: Systematic Review and Meta-Analysis of Retrospective Studies, on Behalf of the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation
Alotaibi H, Aljurf M, de Latour R, Alfayez M, Bacigalupo A, Fakih R E, Schrezenmeier H, Ahmed S O, Gluckman E, Iqbal S, Höchsmann B, Halkes C, de la Fuente J, Alshenry N, Cesaro S, Passweg J, Dufour C, Risitano A M, DiPersio J, Motabi I
Transplantation and Cellular Therapy 28(2):105.e1-105.e7
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Impact of the human leucocyte antigen (HLA)-B leader peptide dimorphism and HLA-A expression on outcomes of stem cell transplantation for sickle cell disease
Cappelli B, Scigliuolo G, Boukouaci W, Rafii H, Volt F, Kenzey C, Maio K T, Chabannon C, Corbacioglu S, Rocha V, Ruggeri A, Gluckman E, Tamouza R
BJH doi: 10.1111/bjh.17665 -
Systematic review/meta-analysis on efficacy of allogeneic HCT in sickle cell disease: an international effort on behalf of the Pediatric Diseases Working Party of EBMT and the Sickle Cell Transplantation International Consortium
Iqbal M, Reljic T, Corbacioglu S, de la Fuente J, Gluckman E, Kumar A, Yassine F, Ayala E, El-Jawahri A, Murthy H, Almohareb F, Hashmi S K, Cappelli B, Alahmari A, Scigliuolo G, Kassim A, Aljurf M, Kharfan-Dabaja M A
Transplantation and Cellular Therapy 27(2): 167.e1-167.e12 -
Umbilical cord blood transplants facilitated by the French cord blood banks network. On behalf of the Agency of Biomedicine, Eurocord and the French society of bone marrow transplant and cell therapy (SFGM-TC)
Rafii H, Garnier F, Ruggeri A, Ionescu I, Ballot C, Bensoussan D, Chabannon C, Dazey B, De Vos J, Gautier E, Giraud C, Larghero J, Cras A, Mialou V, Persoons V, Pouthiers F, Thibert J-B, Dalle J-H, Michel G, Kenzey C, Volt F, Rocha V, Bay J-O, Rubio M-T, Faucher C, Marry E, Gluckman E
Bone Marrow Transplant doi.org/10.1038/s41409-021-01313-x
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Alternative donor hematopoietic stem cell transplantation for sickle cell disease in Europe
Gluckman E, Cappelli B, Scigliuolo G, De la Fuente J, Corbacioglu S
Hematol Oncol Stem Cell Ther pii: S1658-3876(20)30034-0 -
An Evaluation of Three Ways of Communicating Carrier Status Results to the Parents of Children in a Neonatal Sickle Cell Screening Programme
Rémus C, Stanislas A, Bouazza N, Gauthereau V, Polak M, Blanche S, Niakaté A, Gluckman E, Tréluyer J-M, Munnich A, Girot R, Cavazzana M
Frontiers in Pediatrics 8(300):1-7 -
Extensive multilineage analysis in patients with mixed chimerism after allogeneic transplantation for sickle cell disease: insight into hematopoiesis and engraftment thresholds for gene therapy
Magnani A, Pondarré C, Bouazza N, Magalon J, Miccio A, Six E, Roudaut C, Arnaud C, Kamdem A, Touzot F, Gabrion A, Magrin E, Couzin C, Fusaro M, André I, Vernant J-P, Gluckman E, Bernaudin F, Bories D, Cavazzana M
Haematologica 105(5): 1240-1247 -
Haploidentical hematopoietic stem cell transplantation in aplastic anemia: a systematic review and meta-analysis of clinical outcome on behalf of the severe aplastic anemia working party of the European group for blood and marrow transplantation (SAAWP of EBMT).
ElGohary G, El Fakih R, de Latour R, Risitano A, Marsh J, Schrezenmeier H, Gluckman E, Höchsmann B, Pierri F, Halkes C, Alzahrani H, De la Fuente J, Cesaro S, Alahmari A, Ahmed S O, Passweg J, Dufour C, Bacigalupo A, Aljurf M
Bone Marrow Transplant doi: 10.1038/s41409-020-0897-2 -
Human leukocyte antigen matched unrelated donors for patients with sickle cell disease: results of international donor searches
Tozatto-Maio K, Torres M A, Degaide N H S, Cardoso J F, Volt F, Silva Pinto A C, Oliveira D, Elayoubi H, Kashima S, Loiseau P, Veelken J H, Ferster A, Cappelli B, Rodrigues E S, Scigliuolo G, Kenzey C, Ruggeri A, Rocha V, Simões B P, Tamouza R, Gluckman E
Biol Blood Marrow Transplant doi.org/10.1016/j.bbmt.2020.07.015 -
Impact of detectable measurable residual disease on umbilical cord blood transplantation
Baron F, Labopin M, Ruggeri A, Sierra J, Robinson S, Labussière-Wallet H, Potter M, Ribera J-M, Deconinck E, Rambaldi A, Rohrlich P-S, de Revel T, Gluckman E, Nagler A, Mohty M
Am J Hematol doi.org/10.1002/ajh.25879 -
Long-term event-free survival, chimerism and fertility outcomes in 234 patients with sickle-cell anemia younger than 30 years after myeloablative conditioning and matched-sibling transplantation in France
Bernaudin F, Dalle J-H, Bories D, de Latour, R P, Robin M, Bertrand Y, Pondarre C, Vannier J-P, Neven B, Kuentz M, Maury S, Lutz P, Paillard C, Yakouben K, Thuret I, Galambrun C, Dhedin N, Jubert C, Rohrlich P, Bay J-O, Suarez F, Raus N, Vernant J-P, Gluckman E, Poirot C, Socié G, Société Française de Greffe de Moelle et de Thérapie Cellulaire
Haematologica 105(1): 91-101 -
Nonmyeloablative Alternative Donor Transplantation for Hodgkin and Non-Hodgkin Lymphoma: From the LWP-EBMT, Eurocord, and CIBMTR
Fatobene G, Rocha V, St Martin A, Hamadani M, Robinson S, Bashey A, Boumendil A, Brunstein C, Castagna L, Dominietto A, Finel H, Chalandon Y, Kenzey C, Kharfan-Dabaja M, Labussière-Wallet H, Moraleda J M, Pastano R, Perales M A, El Ayoubi H R, Ruggeri A, Sureda A, Volt F, Yakoub-Agha I, Zhang M J, Gluckman E, Montoto S, Eapen M
J Clin Oncol 38(14): 1518-1526 -
Optimizing selection of double cord blood units for transplantation of adult patients with malignant diseases
Fatobene G, Volt F, Moreira F, Mariano L, Chevallier P, Furst S, Labussière-Wallet H, Peffault de la Tour R, Deconinck E, Cluzeau T, Russell N, Karakasis D, Forcade E, Ruggeri A, Gluckman E, Rocha V
Blood Advances 4(24): 6327-6335 -
Polymorphisms in Inflammatory Genes Modulate Clinical Complications in Patients With Sickle Cell Disease
Tozatto-Maio K, Girot R, Ly I D, Silva Pinto A C, Rocha V, Fernandes F, Diagne I, Benzerara Y, Dinardo C L, Pavan Soler J, Kashima S, Araujo I L, Kenzey C, Fonseca G H H , Rodrigues E S, Volt F, Jarduli L, Ruggeri A, Mariaselvam C, Gualandro S F M , Rafii H, Cappelli B, Melo Nogueira F, Scigliuolo G, Guerino-Cunha R L, Ribeiro-Malmegrim K, Simoes B P, Gluckman E, Tamouza R
Front Immunol 11: 2041 -
Prognostic factors for adult single cord blood transplantation among European and Japanese populations: the Eurocord/ALWPEBMT and JSHCT/JDCHCT collaborative study
Kanda J, Hayashi H, Ruggeri A, Kimura F, Volt F, Takahashi S, Labopin M, Kako S, Tozzato-Maio K, Yano S, Sanz G, Uchida N, Van Lint M T, Kato S, Mohty M, Forcade E, Kanamori H, Sierra J, Ohno Y, Saccardi R, Fukuda T, Ichinohe T, Takanashi M, Rocha V, Okamoto S, Nagler A, Atsuta Y, Gluckman E
Leukemia 34(1): 128-137 -
Risk score to predict event-free survival after hematopoietic cell transplant for sickle cell disease
Brazauskas R, Scigliuolo G, Wang H-L, Cappelli B, Ruggeri A, Fitzhugh C D, Hankins J S, Kanter J, Meerpohl J J, Panepinto J A, Rondelli D, Shenoy S, Walters M C, Wagner J E, Tisdale J F, Gluckman E, Eapen M
Blood 136(5): 623-626 -
The role of haematopoietic stem cell transplantation for sickle cell disease in the era of targeted disease-modifying therapies and gene editing
de la Fuente J, Gluckman E, Makani J, Telfer P, Faulkner L, Corbacioglu S, Amrolia P, Ansari M, Balduzzi A, Dalassier A, Dalle J-H, Hereda Diaz C, Feuchtinger T, Locatelli F, Lucchini G, Galimard J-E, Gonzalez V M , Handgretinger R, Kleinschmidt K, Lawitschka A, Perez Martinez A, Peters C, Rocha V, Ruggeri A, Sedlacek P, Svec P, Toporski J, Yesilipek A
Lancet Haem 7(12): e902-911 -
The role of HLA matching in unrelated donor hematopoietic stem cell transplantation for sickle cell disease in Europe
Gluckman E, Fuente J, Cappelli B, Scigliuolo G, Volt F, Tozzato-Maio K, Rocha V, Tommaso M, O'Boyle F, Smiers F, Cunha-Riehm C B D , Calore E, Bonanomi S, Graphakos S, Paisiou A, Albert M H, Ruggeri A, Zecca M, Lankester A C, Corbacioglu S, Paediatric Diseases (PDWP), Inborn Errors Working Parties (IEWP) of the EBMT
Bone Marrow Transplant 55: 1946-1954 -
Use of the HLA-B leader to optimize cord-blood transplantation
Petersdorf E W, Gooley T, Volt F, Kenzey C, Madrigal A, McKallor C, Querol S, Rafii H, Rocha V, Tamouza R, Chabannon C, Ruggeri A, Gluckman E
Haematologica doi:10.3324/haematol.2020.264424
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A Toll‐like receptor 2 genetic variant modulates occurrence of bacterial infections in patients with sickle cell disease
Tozatto-Maio K, Girot R, Ly I D, Rocha V, Silva Pinto A C, Diagne I, Benzerara Y, Dinardo C L, Kashima S, Leston-Araujo I, Kenzey C, Fonseca G H H , Rodrigues E S, Volt F, Jarduli L R, Ruggeri A, Mariaselvam C M, Gualandro S F M, Elayoubi H, Cunha R, Cappelli B, Malmegrim K C R, Simoes B P, Gluckman E, Tamouza R
BJH 185(5): 918-924 -
Cord blood transplantation is associated with good outcomes in secondary Acute Myeloid Leukaemia in first remission.
Baron F, Labopin M, Ruggeri A, Volt F, Mohty M, Blaise D, Chevallier P, Sanz J, Fegueux N, Cornelissen J J, Rambaldi A, Savani B N, Gluckman E, Nagler A
J Intern Med 285(4):446-454 -
Effect of donor type and conditioning regimen intensity on allogeneic transplantation outcomes in patients with sickle cell disease: a retrospective multicentre, cohort study.
Eapen M, Brazauskas R, Walters M C, Bernaudin F, Bo-Subait K, Fitzhugh C D, Hankins J S, Kanter J, Meerpohl J J, Bolanos-Meade J, Panepinto J A, Rondelli D, Shenoy S, Williamson J, Woolford T L, Gluckman E, Wagner J E, Tisdale J F
Lancet Haem 6(11):e585-e596 -
Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leukemia, a comparative study from Eurocord and the ALWP EBMT
Ruggeri A, Labopin M, Savani B, Paviglianiti A, Blaise D, Volt F, Ciceri F, Bacigalupo A, Tischer J, Chevallier P, Koc Y, Cornelissen J J, Ehninger G, Sanz G, Deconinck E, Rocha V, Baron F, Mohty M, Gluckman E, Nagler A
Bone Marrow Transplant 54(12):1987-1994 -
Hemoglobinopathies (Sickle Cell Disease and Thalassemia)
Cappelli B, Gluckman E, Ghanem K, Abboud M R
The EBMT Handbook, Hematopoietic Stem Cell Transplantation and Cellular Therapies Part IX Indications and Results (79): 595-601 -
Myeloablative Unrelated Cord Blood Transplantation in Adolescents and Young Adults with Acute Leukemia.
Hayashi H, Volt F, Sanz J, Petersen E, Dhedin N, Hough R, Milpied N, Angelucci E, Yakoub-Agha I, Michallet M, Michel G, Aljurf M, Kenzey C, Rocha V, Dalle J H, Bader P, Ruggeri A, Gluckman E
Biol Blood Marrow Transplant S1083-8791(19): 30503-30508 -
Risk factors affecting outcome of unrelated cord blood transplantation for children with familial haemophagocytic lymphohistiocytosis
Furtado-Silva J M, Paviglianiti A, Ruggeri A, Boelens J J, Veys P, Ahmari A A, Zecca M, Locatelli F, Michel G, Volt F, Kenzey C, Sedlacek P, Rao K, Lankester A, Gluckman E, Rocha V
Br J Haematol 184(3): 397-404 -
Risk factors and outcomes according to age at transplantation with an HLA-identical sibling for sickle cell disease
Cappelli B, Volt F, Tozatto-Maio K, Scigliuolo G, Ferster A, Dupont S, Pinto Simoes B, Al-Seraihy A, Aljurf M D, Almohareb F, Belendez C, Matthes S, Dhedin N, Pondarre C, Dalle J-H, Bertrand Y, Vannier J-P, Kuentz M, Lutz P, Michel G, Rafii H, Neven B, Zecca M, Bader P, Cavazzana M, Labopin M, Locatelli F, Magnani A, Ruggeri A, Rocha V, Corbacioglu SJ, Bernaudin F, de La Fuente J, Corbacioglu S, Gluckman E
Haematologica 104(6) -
Worldwide Network for Blood & Marrow Transplantation (WBMT) special article, challenges facing emerging alternate donor registries
Aljurf M, Weisdorf D, Alfraih F, Szer J, Müller C, Confer D, Hashmi S, Kröger N, Shaw B E, Greinix H, Kharfan-Dabaja M A, Foeken L, Seber A, Ahmed S, El-Jawahri A, Al-Awwami M, Atsuta Y, Pasquini M, Hanbali A, Alzahrani H, Okamoto S, Gluckman E, Mohty M, Kodera Y, Horowitz M, Niederwieser D, El Fakih R
Bone Marrow Transplant 54(8):1179-1188
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Chronic graft-versus-host disease features in double unit cord blood transplantation according to National Institutes of Health 2005 cGVHD Consensus criteria
Hayashi H, Ruggeri A, Volt F, Cornelissen J J, Socié G, Sengeloev H, Michallet M, Karakasis D, Petersen E, Cahn J Y, Veelken H, Mercier M, Rohrlich P-S, Rafii H, Kenzey C, Xavier E, Duarte R F, Basak G W, Rocha V, Gluckman E
Am J Physiol Regul Integr Comp Physiol 53(4): 417-421 -
Cord Blood Unit Dominance Analysis and Effect of the Winning Unit on Outcomes after Double-Unit Umbilical Cord Blood Transplantation in Adults with Acute Leukemia: A Retrospective Study on Behalf of Eurocord, the Cord Blood Committee of Cellular Therapy, Immunobiology Working Party, and the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
Tozatto-Maio K, Giannotti F, Labopin M, Ruggeri A, Volt F, Paviglianiti A, Kenzey C, Hayashi H, Cornelissen J, Michallet M, Karakasis D, Deconinck E, Rohrlich P S, de la Tour R P, Blaise D, Petersen E, D'Aveni M, Sengeloev H, Lamy T, Russell N H, Forcade E, Craddock C F, Nagler A, Gluckman E, Rocha V
Biol Blood Marrow Transplant pii: S1083-8791(18)30092-2 -
Endothelial and Circulating Progenitor Cells in Hematological Diseases and Allogeneic Hematopoietic Stem Cell Transplantation
Ruggeri A, Paviglianiti A, Volt F, Kenzey C, Rafii H, Rocha V, Gluckman E
Curr Med Chem 25(35): 4535-4544 -
Hematopoeitic Stem Cell Transplantation Outcome Data Management: Importance of Establishing an Institutional Database
Tucunduva L, Gluckman E, Rocha V
Establishing a hematopoietic stem cell transplantation unit Chap. 17: 245-255 -
Low Body Mass Index Is Associated with Increased Risk of Acute GVHD after Umbilical Cord Blood Transplantation in Children and Young Adults with Acute Leukemia: A Study on Behalf of Eurocord and the EBMT Pediatric Disease Working Party
Paviglianiti A, Dalle J H, Ayas M, Boelens J J, Volt F, Iori A P, de Souza M P, Diaz M A, Michel G, Locatelli F, Jubert C, Yakoub-Agha I, Bittencourt H, Bertrand Y, Kenzey C, Tozatto Maio K, Hayashi H, Rocha V, Bader P, Gluckman E, Ruggeri A
Biol Blood Marrow Transplant 24(4): 799-805 -
Occurrence of graft-versus-host disease increases mortality after umbilical cord blood transplantation for acute myeloid leukaemia: a report from Eurocord and the ALWP of the EBMT
Baron F, Ruggeri A, Beohou E, Labopin M, Mohty M, Sanz J, Vigouroux S, Furst S, Bosi A, Chevallier P, Cornelissen J J, Michallet M, Sierra J, Karakasis D, Savani B N, Gluckman E, Nagler A
J Intern Med 283(2): 178-189 -
Outcomes of Advanced Hodgkin Lymphoma after Umbilical Cord Blood Transplantation: A Eurocord and EBMT Lymphoma and Cellular Therapy & Immunobiology Working Party Study
Paviglianiti A, Tozzato Maio K, Rocha V, Gehlkopf E, Milpied N, Esquirol A, Chevallier P, Blaise D, Gac A C, Leblond V, Cahn J Y, Abecassis M, Zuckerman T, Schouten H, Gurman G, Rubio M T, Beguin Y, Corral L L, Nagler A, Snowden J A, Koc Y, Mordini N, Bonifazi F, Volt F, Kenzey C, Robinson S P, Montoto S, Gluckman E, Ruggeri A
Biol Blood Marrow Transplant 24(11): 2265-2270 -
Sickle SCAN (BioMedomics) fulfills analytical conditions for neonatal screening of sickle cell disease
Nguyen-Khoa T, Mine L, Allaf B, Ribeil J A, Remus C, Stanislas A, Gauthereau V, Enouz S, Kim J S, Yang X, Gluckman E, Beaudeux J L, Munnich A, Girot R, Cavazzana M
Ann Biol Clin 76(4): 416-420 -
Transfusion-related adverse events are decreased in pregnant women with sickle cell disease by a change in policy from systematic transfusion to prophylactic oxygen therapy at home: A retrospective survey by the international sickle cell disease observatory
Ribeil J A, Labopin M, Stanislas A, Deloison B, Lemercier D, Habibi A, Albinni S, Charlier C, Lortholary O, Lefrere F, De Montalembert M, Blanche S, Galactéros F, Tréluyer J M, Gluckman E, Ville Y, Joseph L, Delville M, Benachi A, Cavazzana M
Am J Hematol 93(6): 794-802
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A risk factor analysis of outcomes after unrelated cord blood transplantation for children with Wiskott-Aldrich syndrome
Shekhovtsova Z, Bonfim C, Ruggeri A, Nichele S, Page K, Al Seraihy A, Barriga F, de Toledo Codina J S, Veys P, Boelens J J, Mellgren K, Bittencourt H, O'Brien T, Shaw P J, Chybicka A, Volt F, Giannotti F, Gluckman E, Kurtzberg J, Gennery A R, Rocha V
Haematologica 102(6): 1112-1119 -
An Integrative Scoring System for Survival Prediction Following Umbilical Cord Blood Transplantation in Acute Leukemia
Shouvai R, Ruggeri A, Labopin M, Mohty M, Sanz G, Michel G, Kuball J, Chevallier P, Al-Seraihy A, Milpied N-J, Diaz de Heredia C, Arcese W, Blaise D, Rocha V, Fein J, Unger R, Baron F, Bader P, Gluckman E, Nagler A
Clin Cancer Res 23(21): 6478 -
Establishing a Hematopoietic Stem Cell Transplantation Unit. A practical Guide
Gluckman E, Niederwieser D, Aljurf M D
Springer Edition Number 1, XIV, 306p. -
Evaluation of a disease risk index for adult patients undergoing umbilical cord blood transplantation for haematological malignancies.
Paviglianiti A, Ruggeri A, Volt F, Sanz G, Milpied N, Furst S, Esquirol A, Arcese W, Picardi A, Ferra C, Ifrah N, Bourhis J H, Raj K, von dem Borne P A, Sica S, Menard A L, Bloor A, Kenzey C, Gluckman E, Rocha V
Br J Haematol 179(5): 790-801 -
Factors Associated with Long-Term Risk of Relapse after Unrelated Cord Blood Transplantation in Children with Acute Lymphoblastic Leukemia in Remission
Page K M, Labopin M, Ruggeri A, Michel G, Diaz de Heredia C, O'Brien T, Picardi A, Ayas M, Bittencourt H, Vora A J, Troy J, Bonfim C, Volt F, Gluckman E, Bader P, Kurtzberg J, Rocha V, Duke University Cord Blood Committee- Cellular Therapy, Immunobiology Working Party (CBC-CTIWP) Paediatric Disease Working Party (PDWP) of EBMT, Eurocord
Biol Blood Marrow Transplant 23()8: 1350-1358 -
Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks
Rafii H, Bernaudin F, Rouard H, Vanneaux V, Ruggeri A, Cavazzana M, Gaulthereau V, Stanislas A, Benkerrou M, De Montalembert M, Ferry C, Girot R, Arnaud C, Kamdem A, Gour J, Touboul C, Cras A, Kuentz M, Rieux C, Volt F, Cappelli B, Maio K T, Paviglianiti A, Larghero J, Gluckman E
Haematologica 102(6): 976-983 -
Historical Perspective and Current Trends of Umbilical Cord Blood Transplantation
Gluckman E, Ruggeri A
Cord Blood Transplantation / Advances and Controversies in Hematopoietic Transplantation and Cell Therapy Chap. 1: 1-12 -
Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation
Cunha R, Zago M A, Querol S, Volt F, Ruggeri A, Sanz G, Pouthier F, Kogler G, Vicario J L, Bergamaschi P, Saccardi R, Lamas C H, Diaz de Heredia C, Michel G, Bittencourt H, Tavella M, Panepucci R A, Fernandes F, Pavan J, Gluckman E, Rocha V
Blood 129: 525-532 -
Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients
Farge D, Arruda L C M , Brigant F, Clave E, Douay C, Marjanovic Z, Deligny C, Maki G, Gluckman E, Moins-Teisserenc H
J Hematol Oncol. 10: 21 -
Long-Term Outcomes of Cord Blood Transplantation from an HLA-Identical Sibling for Patients with Bone Marrow Failure Syndromes: A Report From Eurocord, Cord Blood Committee and Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation
Pagliuca S, Peffault de Latour R, Volt F, Locatelli F, Zecca M, Dalle J-H, Comoli P, Vettenranta K, Diaz MA, Reuven O, Bertrand Y, Diaz de Heredia C, Nagler H, Ghavamzadeh A, Sufliarska S, Lawson S, Kenzey C, Rocha V, Dufour C, Gluckman E, Passweg J, Ruggeri A
Biol Blood Marrow Transplant 23(11): 1939-1948 -
Outcomes of UCB transplantation are comparable in FLT3+ AML: Results of CIBMTR, eurocord and EBMT collaborative analysis
Ustun C, Giannotti F, Zhang M J, Wang H L, Brunstein C, Labopin M, Rocha V, de Lima M, Baron F, Sandmaier B M, Eapen M, Gluckman E, Nagler A, Weisdorf D J, Ruggeri A
Leukemia 31(6): 1408-1414 -
Red blood cell alloimmunisation in patients with sickle cell disease
Volt F
Lancet Haem 4(11): e506-507 -
Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation
Gluckman E, Cappelli B, Bernaudin F, Labopin M, Volt F, Carreras J, Simoes B P, Ferster A, Dupont S, de la Fuente J, Dalle J-H, Zecca M, Walters M C, Krishnamurti L, Bhatia M, Leung K, Yanik G, Kurtzberg J, Dhedin N, Kuentz M, Michel G, Apperley J, Lutz P, Neven B, Bertrand Y, Vannier J P, Ayas M, Cavazzana M, Matthes-Martin S, Rocha V, Elayoubi H, Kenzey C, Bader P, Locatelli F, Ruggeri A, Eapen M
Blood 129(11): 1548-1556 -
Single- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT
Baron F, Ruggeri A, Beohou E, Labopin M, Mohty M, Blaise D, Cornelissen J J, Chevallier P, Sanz G, Petersen E, Savani B N, Gluckman E, Nagler A
J Hematol Oncol. 10: 128 -
Umbilical Cord Blood Cytomegalovirus Serostatus Does Not Have an Impact on Outcomes of Umbilical Cord Blood Transplantation for Acute Leukaemia
Nikolajeva O, Rocha V, Danby R, Ruggeri A, Volt F, Baudoux E, Gomez G S, Kogler G, Larghero J, Lecchi L, Martinez M S, Navarrete C, Pouthiers F, Querol S, Kenzey C, Szydlo R, Gluckman E, Madrigal A
Biol Blood Marrow Transplant 23(10): 1729-1735 -
Unrelated Cord Blood Transplantation for Acute Leukemia Diagnosed in the First Year of Life: Outcomes and Risk Factor Analysis
Ruggeri A, Volt F, Locatelli F, Michel G, Diaz de Heredia C, Abecasis M, Zecca M, Vora A, Yakouben K, O'Brien T A, Giardino S, Cornish J, Rocha V, Peters C, Bader P, Gluckman E, Dalle J H
Biol Blood Marrow Transplant 23(1): 96-102
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Changing Trends of Unrelated Umbilical Cord Blood Transplantation for Hematologic Diseases in Patients Older than Fifty Years: A Eurocord-Center for International Blood and Marrow Transplant Research Survey
Rafii H, Ruggeri A, Volt F, Brunstein C G, Carreras J, Eapen M, Gluckman E, Weisdorf D J
Biol Blood Marrow Transplant 22: 1717-1720 -
Impact of cord blood banking technologies on clinical outcome: a Eurocord/Cord Blood Committee (CTIWP), European Society for Blood and Marrow Transplantation and NetCord retrospective analysis
Saccardi R, Tucunduva L, Ruggeri A, Ionescu I, Koegler G, Querol S, Grazzini G, Lecchi L, Nanni Costa A, Navarrete C, Pouthiers F, Larghero J, Regan D, Freeman T, Bittencourt H, Kenzey C, Labopin M, Baudoux E, Rocha V, Gluckman E
Transfusion 56(8): 2021-2029 -
Impact of HLA in cord blood transplantation outcomes
Ruggeri A, Paviglianiti A, Gluckman E, Rocha V
HLA 87(6): 413-421 -
Killer cell immunoglobulin-like receptor ligand matching and outcomes after unrelated cord blood transplantation acute myeloid leukemia
Rocha V, Ruggeri A, Spellman S, Wang T, Sobecks R, Locatelli F, Askar M, Michel G, Arcese W, Iori A P, Purtill D, Danby R, Sanz G F, Gluckman E, Eapen M
Biol Blood Marrow Transplant 22(7): 1284-1289 -
Outcomes after Unrelated Umbilical Cord Blood Transplantation for Children with Osteopetrosis
Chiesa R, Ruggeri A, Paviglianiti A, Zecca M, Gonzalez-Vincent M, Bordon V, Stein J, Lawson S, Dupont S, Dini G, Abecasis M, Al-Seraihy A, Kenzey C, Bierings M, Locatelli F, Gluckman E, Schulz A, Gennery A, Page K, Kurtzberg J, Rocha V
Biol Blood Marrow Transplant 22(11): 1997-2002 -
Outcomes of unrelated cord blood transplantation in patients with multiple myeloma: a survey on behalf of Eurocord, the Cord Blood Committee of Cellular Therapy and Immunobiology Working Party, and the Chronic Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Paviglianiti A, Xavier E, Ruggeri A, Ceballos P, Deconinck E, Cornelissen J J, Nguyen-Quoc S, Maillard N, Sanz G, Rohrlich P-S, Garderet L, Volt F, Rocha V, Kroeger N, Gluckman E, Fegueux N, Mohty M
Haematologica 101(9): 1120-1127 -
RIC versus MAC UCBT in adults with AML: A report from Eurocord, the ALWP and the CTIWP of the EBMT.
Baron F, Ruggeri A, Beohou E, Labopin M, Sanz G, Milpied N, Michallet M, Bacigalupo A, Blaise D, Sierra J, Socie G, Cornelissen J J, Schmid C, Giebel S, Gorin N C, Esteve J, Ciceri F, Savani B N, Mohty M, Gluckman E, Nagler A
Oncotarget 7(28): 43027-43038 -
Unrelated Cord Blood Transplantation in adults: evolution, experience and long-term outcomes in the UK National Health Service : a retrospective analysis on behalf of the British Society of Blood and Marrow Transplantation and Eurocord
Snowden J A, Danby R, Ruggeri A, Marks D I, Hough R E, Pagliuca A, Potter M, Russell N, Craddock C, Clark A, Miller P, Cook G, Gluckman E, Shaw B E, Rocha V
Br J Haematol 172(3): 478-481
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Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia
Ruggeri A, Labopin M, Sanz G, Piemontese S, Arcese W, Bacigalupo A, Blaise D, Bosi A, Huang H, Karakasis D, Koc Y, Michallet M, Picardi A, Sanz J, Santarone S, Sengelov H, Sierra J, Vincent L, Volt F, Nagler A, Gluckman E, Ciceri F, Rocha V, Mohty M
Leukemia 29(9): 1891-1900 -
Influence of glutathione S-transferase gene polymorphisms on busulfan pharmacokinetics and outcome of hematopoietic stem-cell transplantation in thalassemia pediatric patients.
Ansari M, Huezo-Diaz P, Rezguli M A, Marktel S, Duval M, Bittencourt H, Cappelli B, Krajinovic M
Bone Marrow Transplant 1-7 -
Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood--a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation
Baron F, Labopin M, Ruggeri A, Mohty M, Sanz G, Milpied N, Bacigalupo A, Rambaldi A, Bonifazi F, Bosi A, Sierra J, Yakoub-Agha I, Santasusana J M, Gluckman E, Nagler A
J Hematol Oncol. 8(1): 107 -
Unrelated cord blood transplantation for childhood acute myelogenous leukemia: The influence of cytogenetic risk group stratification
Michel G, Cunha R, O'Brien T A, Bittencourt H, Dalle J H, Locatelli F, Iori A P, Mauad M, Oudin C, Giannotti F, Volt F, Gluckman E, Bader P, Rocha V
Leukemia 30(5): 1180-1183
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Engraftment kinetics and graft failure after single umbilical cord blood transplantation using a myeloablative conditioning regimen
Ruggeri A, Labopin M, Sormani M P, Sanz G, Sanz J, Volt F, Michel G, Locatelli F, Diaz de Heredia C, O'Brien T, Arcese W, Iori A P, Querol S, Kogler G, Lecchi L, Pouthier F, Garnier F, Navarrete C, Baudoux E, Fernandes J, Kenzey C, Eapen M, Gluckman E, Rocha V, Saccardi R
Haematologica 99(9): 1509-1515 -
Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis
Robin M, Giannotti F, Deconinck E, Mohty M, Michallet M, Sanz G, Chevallier P, Cahn J Y, Legrand F, Rovira M, Passweg J, Sierra J, Nguyen S, Maillard N, Yakoub-Agha I, Linkesch W, Cannell P, Marcatti M, Bay J O, Chalandon Y, Kroger N, Gluckman E, Rocha V, Olavarria E, Ruggeri A
Biol Blood Marrow Transplant 20(11): 1841-1846