Annuaire du CSM

Thèmes de recherche développés

- Signalisation hypoxique et métabolisme
- Stress acide, nutritionnel et oxydant dans les cancers


Au fil des ans, l’équipe ‘Pouysségur’ a combiné la génétique et la biologie moléculaire pour étudier les mécanismes d’action des facteurs de croissance et a caractérisé les principales voies de signalisation contrôlant la prolifération cellulaire. Cette équipe a apporté une contribution majeure aux domaines des glycoprotéines, de l’adhésion cellulaire, du métabolisme, de la régulation du pH intracellulaire et de l'identification moléculaire de l’échangeur Na⁺/H⁺ humain. De plus, l’équipe a établi que le pH intracellulaire et les MAP kinase (ERK1/2) sont essentielles à l’activation de mTORC1 et au contrôle de l'entrée des cellules dans le cycle cellulaire.
Au cours des 25 dernières années, l’équipe a tourné son intérêt vers un autre mécanisme de croissance essentiel: par quels mécanismes les cellules contrôlent-elles leur apport en nutriments? Ce processus clé a conduit l’équipe à étudier les mécanismes de signalisation des proline hydroxylases (PHDs), l’expression de HIF1 sous hypoxie, de l'angiogenèse, de l’autophagie, du stress nutritionnel et du métabolisme aberrant des tumeurs.
Actuellement, l’équipe poursuit, à un niveau fondamental, translationnel et pré-clinique, le rôle physiologique des cibles clés induites par le stress nutritionnel et l’hypoxie tumorale. L'accent est mis sur le métabolisme du glucose fermentatif exacerbé (effet Warburg) ou oxydatif au sein des tumeurs, l'importation d’acides aminés sous l'influence de HIF ou du stress oxydant. De nombreuses cibles anticancéreuses inactivées par Zinc Finger Nucléases et/ou CRISPR-Cas9 (anhydrases carboniques CA9, CA12, CA2, transporteurs de bicarbonate NBC, transporteurs d’acide lactique MCT1, MCT4, leur chaperone CD147/basigine, transporteurs d'acide amminés clé : LAT1, ASCT2, xCT et leurs chaperones CD98, CD44…) ont été analysées sur lignées tumorales (colon, mélanome, sein, pancréas, poumon). Ces cibles, souvent fortement exprimées dans les cancers agressifs, contribuent à la sélection «darwinienne» dans le microenvironnement tumoral hypoxique, acide, dénutri conduisant à la dissémination métastatique
 
Citations du Web of Science: 49500, facteur h 123
Citations Google Scholar: 60750, facteur h 134

Publications CSM

2022

• 'Warburg effect' controls tumor growth, bacterial, viral infections and immunity - Genetic deconstruction and therapeutic perspectives
  Pouyssegur J, Marchiq I, Parks S K, Durivault J, Zdralevic M, Vucetic M
  Semin Cancer Biol Vol.86, Part 2, pp. 334-346
• Genetic Disruption of the γ-Glutamylcysteine Ligase in PDAC Cells Induces Ferroptosis-Independent Cell Death In Vitro without Affecting In Vivo Tumor Growth
  Daher B, Meira W, Durivault J, Gotorbe C, Pouyssegur J, Vucetic M
  Cancers 14, 3154
• Metabolic Rewiring toward Oxidative Phosphorylation Disrupts Intrinsic Resistance to Ferroptosis of the Colon Adenocarcinoma Cells
  Gotorbe C, Durivault J, Meira W, Cassim S, Zdralevic M, Pouyssegur J, Vucetic M
  Antiox 11(12), 2412
• Professor Ernesto Carafoli, a scientific monument in biochemistry and biology of calcium signalling
  Pouyssegur J
  Biochem Biophys Res Commun 633 (2022) 6-8

2021

• A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT(KO) Pancreatic Ductal Adenocarcinoma Cells
  Meira W, Daher B, Parks S, Cormerais Y, Durivault J, Tambutté E, Pouyssegur J, Vucetic M
  Cancers 13(1434)
• Amino acid transporters are a vital focal point in the control of mTORC1 signaling and cancer
  Cormerais Y, Vucetic M, Parks S, Pouyssegur J
  Int J Mol Sci 22,23
• Cancer Metabolism and Therapeutic Perspectives: Exploiting Acidic, Nutritional, and Oxidative Stresses
  Zdralevic M, Pouyssegur J
  In 'Rethinking Cancer' Chap. 12: 271-297, Ed. B Strauss, M Bertolaso, I Ernberg & MJ Bissel
• Hypoxia and hypoxia-inducible factors promote the development of neointimal hyperplasia in arteriovenous fistula
  Sadaghianloo N, Contenti J, Declemy S, Ambrosetti D, Zdralevic M, Tannour-Louet M, Fabbri L, Pagès G, Bost F, Hassen-Khodja R, Pouyssegur J, Jean-Baptise E, Dardik A, Mazure N M
  J Physiol 599: 2299-2321
• NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner
  Huang C, Santofimia-Castaño P, Liu X, Xia Y, Peng L, Gotorbe C, Neira J L, Tang D, Pouyssegur J, Iovanna J
  Cell Death Discov 7: 269
• Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT Inhibitors
  Vucetic M, Daher B, Cassim S, Parks S, Pouyssegur J
  In Ferroptosis: Mechanism and Diseases, Advances in Experimental Medicine and Biology A. F. Florez, H. Alborzinia (eds.), 1301: 7-24
• Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response
  Schwab M, Thunborg K, Azimzadeh O, von Toerne C, Werner C, Shevtsov M, Di Genio T, Zdralevic M, Pouyssegur J, Renner K, Kreutz M, Multhoff G
  Cancers 13, 3762

2020

• Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia
  Sadaghianloo N, Contenti J, Dufies M, Parola J, Rouleau M, Lee S, Peyron J-F, Fabbri L, Hassen-Khodja R, Pouyssegur J, Bost F, Jean-Baptiste E, Dardik A, Mazure N M
  J Cell Mol Med 24(5): 2931-2941
• Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death
  Daher B, Vucetic M, Pouyssegur J
  Front Oncol 10: 723
• From Malignant Progression to Therapeutic Targeting: Current Insights of Mesothelin in Pancreatic Ductal Adenocarcinoma
  Montemagno C, Cassim S, Pouyssegur J, Broisat A, Pagès G
  Int J Mol Sci 21(11): 4067
• Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients
  Dufies M, Fabbri L, Lacas-Gervais S, Gardie B, Gad-Lapiteau S, Parola J, Nottet N, Meyenberg Cunha de Padua M, Contenti J, Borchiellini D, Ferrero J-M, Rioux Leclercq N, Ambrosetti D, Mograbi B, Richard S, Viotti J, Chamorey E, Sadaghianloo N, Rouleau M, Craigen W J, Mari B, Clavel S, Pagès G, Pouyssegur J, Bost F, Mazure N M
  Theranostics 10(6): 2696-2713
• Lactate and acidity in the cancer microenvironment
  Parks S, Mueller-Klieser W, Pouyssegur J
  Annu Rev Cancer Biol 4: 141-158
• Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS
  Sun X, Berger R S, Heinrich P, Marchiq I, Pouyssegur J, Renner K, Oefner P J, Dettmer K
  Metabolites 10(7): 292
• Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis
  Vucetic M, Daher B, Cassim S, Meira W, Pouyssegur J
  Cell Death Dis 11, 789: 1-13
• Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response
  Cassim S, Pouyssegur J
  Int J Mol Sci 21(1): E157
• Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer
  Cassim S, Vucetic M, Zdralevic M, Pouyssegur J
  Cancers 12(5): 1119
• Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase
  Mazzio E, Badisa R, Mack N, Cassim S, Zdralevic M, Pouyssegur J, Soliman K F A
  Cancer Genomics & Proteomics 17: 469-497

2019

• 99mTc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma
  Montemagno C, Cassim S, Trichanh D, Savary C, Pouyssegur J, Pagès G, Fagret D, Broisat A, Ghezzi C
  Cancers 11(10): 1531
• Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells
  Guerrini G, Durivault J, Filippi I, Criscuoli M, Monaci S, Pouyssegur J, Naldini A, Carraro F, Parks S
  Biochem Biophys Res Commun 516(2):408-413
• Genetic ablation of the cystine importer xCT induces ferroptosis in pancreatic ductal adenocarcinoma cells
  Vucetic M, Daher B, Durivault J, Pouyssegur J
  Free Radic Biol Med. 139(Suppl. 1): S55
• Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
  Daher B, Parks S, Durivault J, Cormerais Y, Baidarjad H, Tambutté E, Pouyssegur J, Vucetic M
  Cancer Res 79(15):3877-3890
• Hypoxia protects against the cell death triggered by oxovanadium-galactomannan complexes in HepG2 cells
  Cunha-de-Padua M, Noleto G R, de Oliveira Petkowicz C L, Cadena S M S C, Bost F, Pouyssegur J, Mazure N
  Cell Mol Biol Lett 24: 18
• Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma
  Cormerais Y, Pagnuzzi M, Schrötter S, Giuliano S, Tambutté E, Endou H, Wempe M F, Pagès G, Pouyssegur J, Picco V
  J Cell Mol Med 1-8
• Reply to Beltinger: Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism
  Pouyssegur J, Zdralevic M
  J Biol Chem 294(1): 67
• Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
  Renner K, Bruss C, Schnell A, Koehl G, Becker H M, Fante M, Menevse A-N, Kauer N, Blazquez R, Hacker L, Decking S-M, Bohn T, Faerber S, Evert K, Aigle L, Amslinger S, Landa M, Krijgsman O, Rozeman E A, Brummer C, Siska P J, Singer K, Pektor S, Miederer M, Peter K, Gottfried E, Herr W, Marchiq I, Pouyssegur J, Roush W R, Ong S F, Warren S, Pukrop T, Beckhove P, Lang S A, Bopp T, Blank C U, Cleveland J L, Oefner P J, Dettmer K, Selby M, Kreutz M
  Cell Rep 29: 135-150
• Targeting amino acids transporters (SLCs) to starve cancer cells to death
  Cormerais Y, Vucetic M, Pouyssegur J
  Biochem Biophys Res Commun 520: 691-693
• The great joy of a BBRC editor
  Pouyssegur J
  Biochem Biophys Res Commun 520: 694

2018

• AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity
  Brolih S, Parks S, Vial V, Durivault J, Mostosi L, Pouyssegur J, Pagès G, Picco V
  BMC Cancer 18(1): 249
• Double genetic disruption of lactate dehydrogenase A and B is required to ablate the ‘Warburg effect’ restricting tumor growth to oxidative metabolism
  Zdralevic M, Brand A, Di lanni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking S-M, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner P J, Renner K, Pouyssegur J, Kreutz M
  J Biol Chem 293(41): 15947–15961
• Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin
  Persaud A, Cormerais Y, Pouyssegur J, Rotin D
  J Cell Sci 131(1): jcs211755
• Simultaneous positron emission tomography and ultrafast ultrasound for hybrid molecular, anatomical and functional imaging
  Provost J, Garofalakis A, Sourdon J, Bouda D, Berthon B, Viel T, Perez-Liva M, Lussey-Lepoutre C, Favier J, Correia M, Pernot M, Chiche J, Pouyssegur J, Tanter M, Tavitian B
  Nat Biomed Eng 2(2): 85-94
• The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
  Cormerais Y, Massard P-A, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe M F, Parks S, Pouyssegur J
  J Biol Chem 293(8): 2877-2887
• The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma
  Ambrosetti D, Dufies M, Dadone B, Durand M, Borchiellini D, Amiel J, Pouyssegur J, Rioux-Leclercq N, Pagès G, Burel-Vandenbos F, Mazure N
  PLoS ONE 13(2): e0193477
• Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
  Bohn T, Rapp S, Luther N, Klein M, Bruehl T-J, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst H-C, von Stebut E, Becker C, Schild H, Schmitt E, Bopp T
  Nat Immunol 19: 1319–1329

2017

• Disrupting glucose-6-phosphate isomerase fully suppresses the ‘Warburg effect’ and activates OXPHOS with minimal impact on tumor growth except in hypoxia
  Cunha de Padua M, Delodi G, Vucetic M, Durivault J, Vial V, Bayer P, Noleto G, Mazure N, Zdralevic M, Pouyssegur J
  Oncotarget 8(50): 87623-87637
• Disrupting the 'Warburg effect' re-routes cancer cells to OXPHOS offering a vulnerability point via 'ferroptosis'-induced cell death.
  Zdralevic M, Vucetic M, Daher B, Marchiq I, Parks S, Pouyssegur J
  Adv Biol Regul pii: S2212-4926(17): 30189-30196
• Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters
  Tsuji T, Kurokawa Y, Chiche J, Pouyssegur J, Sato H, Fukuzawa H, Nagao M, Kambe T
  J Biol Chem 292(6): 2159-2173
• ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB
  Leduc M, Richard J, Costes S, Muller D, Varrault A, Compan V, Mathieu J, Tanti J F, Pagès G, Pouyssegur J, Bertrand G, Dalle S, Ravier M A
  Diabetologia 60(10): 1999-2010
• Extracellular Signal-Regulated Kinase Signaling in CD4-Expressing Cells Inhibits Osteochondromas
  Wehenkel M, Corr M, Guy C, Edwards B A, Castellaw A H, Calabrese C, Pagès G, Pouyssegur J, Vogel P, McGargill M A
  Front Immunol 8: 482
• Genetic disruption of the pHi-regulating proteins Na⁺/H⁺ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells
  Parks S, Cormerais Y, Durivault J, Pouyssegur J
  Oncotarget 8(6): 10225-10237
• Hypoxia and cellular metabolism in tumour pathophysiology
  Parks S, Cormerais Y, Pouyssegur J
  J Phycol 595(8): 2439-2450
• Integration of a ‘proton antenna’ facilitates transport activity of the monocarboxylate transporter MCT4
  Noor S I, Pouyssegur J, Deitmer J W, Becker H M
  FEBS J 284(1): 149-162
• Metabolic Plasiticy in Cancers-Distinct Role of Glycolytic Enzymes GPI, LDHs or Membrane Transporters MCTs
  Zdralevic M, Marchiq I, de Padua M M C, Parks S, Pouyssegur J
  Front Oncol 7: 313
• Spontaneous chondroma formation in CD2-Cre-driven Erk-deficient Mice
  Shiokawa M, Lu X, Miyake Y, Ishikawa E, Pagès G, Pouyssegur J, Ogata M, Yamasaki S
  Int Immunol 29(10): 479-485
• Targeting pH regulating proteins for cancer therapy-Progress and limitations
  Parks S, Pouyssegur J
  Semin Cancer Biol 43: 66-73
• The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code
  Vucetic M, Cormerais Y, Parks S, Pouyssegur J
  Front Oncol 7(319): 1-15

2016

• ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?
  Busca R, Pouyssegur J, Lenormand P
  Front Cell Dev Biol 4: 53
• Genetic disruption of the multifunctional CD98/LAT1 complex demonstrates the key role of essential amino acid transport in the control of mTORC1 and tumor growth
  Cormerais Y, Giuliano S, Le Floch R, Front B, Durivault J, Tambutté E, Massar P-A, Rodriguez de la Ballina L, Endou H, Wempe M F, Palacin M, Parks S, Pouyssegur J
  Cancer Res 76(15): 4481-4492
• Hypoxia in health and disease
  Pouyssegur J, Lopez-Barneo J
  Mol Aspects Med 47-48: 1-2
• Hypoxia optimises tumour growth by controlling nutrient import and acidic metabolite export
  Parks S, Cormerais Y, Marchiq I, Pouyssegur J
  Mol Aspects Med 47-48: 3-14
• Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H symporters
  Marchiq I, Pouyssegur J
  J Mol Med 94(2): 155-171
• LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
  Brand A, Singer K, Koehl G E, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ulrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner P J, Hoffmann P, Walenta S, Geissler E K, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M
  Cell Metab 24(5): 657-671
• Na⁺/H⁺ antiporter (NHE1) and lactate/H⁺ symporters (MCTs) in pH homeostasis and cancer metabolism
  Counillon L, Bouret Y, Marchiq I, Pouyssegur J
  Biochim Biophys Acta 1863(10): 2465-2480

2015

• AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of ras-transformed fibroblasts
  Pelletier J, Roux D, Viollet B, Mazure N M, Pouyssegur J
  Oncotarget 6(14): 11833-11847
• Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status
  Granja S, Marchiq I, Le Floch R, Moura C S, Baltazar F, Pouyssegur J
  Oncotarget 6(9): 6708-6721
• ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1
  Busca R, Christen R, Lovern M, Clifford A M, Yue J X, Goss G G , Pouyssegur J, Lenormand P
  BMC Evol Biol 15(1): 179
• Genetic Disruption of Lactate/H⁺ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin
  Marchiq I, Le Floch R, Roux D, Simon M P, Pouyssegur J
  Cancer Res 75(1): 171-180
• Knock out of the BASIGIN/CD147 chaperone of Lactate/H⁺ symporters disproves its pro-tumour action via Extracellular Matrix Metalloproteases (MMPs) induction.
  Marchiq I, Albrengues J, Granja S, Gaggioli C, Pouyssegur J, Simon M P
  Oncotarget 6(28): 24636-24648
• Knockout of Vdac1 activates HIF through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation.
  Brahimi-Horn C M, Giuliano S, Saland E, Lacaze-Gervais S, Sheiko T, Pelletier J, Bourget I, Bost F, Féral C, Boulter E, Tauc M, Ivan M, Garmy-Susini B, Popa A, Mari B, Sarry J E, Craigen W J, Pouyssegur J, Mazure N M
  Cancer Metab 3: 8
• Local mitochondrial-endolysosomal microfusion cleaves the voltage-dependent anion channel 1 to promote survival in hypoxia
  Brahimi-Horn C, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michels C, Voeltzel T , Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouyssegur J, Mazure N
  Mol Cell Biol 35(9): 1491-1505
• Monitoring Mitochondrial Pyruvate Carrier Activity in Real Time Using a BRET-Based Biosensor: Investigation of the Warburg Effect
  Compan V, Pierredon S, Vanderperre B, Krznar P, Marchiq I, Zamboni N, Pouyssegur J, Martinou J-C
  Mol Cell 59(3): 491-501
• Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
  Pettersen E O, Ebbesen P, Gieling R G, Williams K J, Dubois L, Lambin P, Ward C, Meehan J, Kunkler I H, Langdon S P, Ree A H, Flatmark K, Lyng H, Calzada M J, Peso L D, Landazuri M O, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton D C, Haider S, Buffa F M, Harris A L, Scozzafava A, Supuran C T, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop K M, Wouters B G, Koritzinsky M, Mujcic H, Cojocari D
  J Enzyme Inhib Med Chem 30(5): 689-721
• The Na⁺/HCO3^- Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells
  Parks S, Pouyssegur J
  J Cell Physiol 230(8): 1954-1963
• Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice
  Yufune S, Satoh Y, Takamatsu I, Ohta H, Kobayashi Y, Takaenoki Y, Pagès G, Pouyssegur J, Endo S, Kazama T
  Sci Rep 20(5): 10252

2014

• Conventional techniques to monitor mitochondrial oxygen consumption
  Simonnet H, Vigneron A, Pouyssegur J
  Meth Enzymol 542: 151-161
• Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome
  Doyen J, Trastour C, Ettore F, Peyrottes I, Toussant N, Gal J, Ilc K, Roux D, Parks S, Ferrero J M, Pouyssegur J
  Biochem Biophys Res Commun 451(1): 54-61
• HIF-Prolyl Hydroxylase 2 Inhibition Enhances the Efficiency of Mesenchymal Stem Cell-Based Therapies for the Treatment of Critical Limb Ischemia
  HoWangYin K-Y, Loinard C, Bakker W, Guérin C L, Vilar J, D'Audigier C, Mauge L, Bruneval P, Emmerich J, Lévy B I, Pouyssegur J, Smadja D M, Silvestre J-S
  Stem Cells 32(1): 231-243

2013

• Disrupting proton dynamics and energy metabolism for cancer therapy
  Parks S, Chiche J, Pouyssegur J
  Nat Rev Cancer 13(9): 611-623
• Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels
  Parks S, Mazure N M, Counillon L, Pouyssegur J
  J Cell Physiol 228(9): 1854-1862
• Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis
  Doyen J, Parks S, Marcie S, Pouyssegur J, Chiche J
  Front Oncol 2: 199
• Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis
  Lutz N W, Le Fur Y, Chiche J, Pouyssegur J, Cozzone P J
  Cancer Res 73(15): 4616-4628
• Tumor hypoxia and metabolism – Towards novel anticancer approaches
  Chiche J, Ricci J-E, Pouyssegur J
  Ann Endocrinol (Paris) 74(2): 111-114