Scientific Directory
M. Jérôme DURIVAULT
Ingénieur d'Études - Équipes : Hypoxie Tumorale et Métabolisme - Mécanismes de Résistance aux Thérapies CibléesTel. +377 97 77 44 25
Email : [javascript protected email address]
CV
Thèmes de recherche développés
Ingénierie des génomes : CRISPR/Cas9 et CRISPR/Cpf1.
Biologie moléculaire et Biologie cellulaire, Biochimie, Microbiologie.
Publications CSM
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The combination of bevacizumab/Avastin and erlotinib/Tarceva is relevant for the treatment of metastatic renal cell carcinoma: the role of a synonymous mutation of the EGFR receptor
Grépin R, Guyot M, Dumond A, Durivault J, Ambrosetti D, Roussel J F, Dupré F, Quintens H, Pagès G
Theranostics 10(3): 1107-1121 -
VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells
Penco-Campillo M, Comoglio Y, Feliz Morel A J, Hanna R, Durivault J, Leloire M, Mejias B, Pagnuzzi M, Morot A, Burel-Vandenbos F, Selby M, Williamson D, Clifford S C, Claren A, Doyen J, Picco V, Martial S, Pagès G
Comm Biol 3(758): 579 -
Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells
Guerrini G, Durivault J, Filippi I, Criscuoli M, Monaci S, Pouyssegur J, Naldini A, Carraro F, Parks S
Biochem Biophys Res Commun 516(2):408-413 -
Genetic ablation of the cystine importer xCT induces ferroptosis in pancreatic ductal adenocarcinoma cells
Vucetic M, Daher B, Durivault J, Pouyssegur J
Free Radic Biol Med. 139(Suppl. 1): S55 -
Genetic ablation of the cystine transporter xCT in pancreatic ductal adenocarcinoma inhibits mTORC1, growth, survival and tumor formation: Implications for potentiating chemosensitivity via erastin
Vucetic M, Daher B, Durivault J, Parks S, Pouyssegur J
Cancer Res 79(13): 880 -
Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
Daher B, Parks S, Durivault J, Cormerais Y, Baidarjad H, Tambutté E, Pouyssegur J, Vucetic M
Cancer Res 79(15):3877-3890 -
VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness
Ndiaye P D, Dufies M, Giuliano S, Douguet L, Grépin R, Durivault J, Lenormand P, Glisse N, Mintcheva J, Vouret-Craviari V, Mograbi B, Wurmser M, Ambrosetti D, Rioux-Leclercq N, Maire P, Pagès G
Theranostics 9(3): 661-675 -
AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity
Brolih S, Parks S, Vial V, Durivault J, Mostosi L, Pouyssegur J, Pagès G, Picco V
BMC Cancer 18(1): 249 -
Double genetic disruption of lactate dehydrogenase A and B is required to ablate the ‘Warburg effect’ restricting tumor growth to oxidative metabolism
Zdralevic M, Brand A, Di lanni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking S-M, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner P J, Renner K, Pouyssegur J, Kreutz M
J Biol Chem 293(41): 15947–15961 -
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
Cormerais Y, Massard P-A, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe M F, Parks S, Pouyssegur J
J Biol Chem 293(8): 2877-2887 -
Disrupting glucose-6-phosphate isomerase fully suppresses the ‘Warburg effect’ and activates OXPHOS with minimal impact on tumor growth except in hypoxia
Cunha de Padua M, Delodi G, Vucetic M, Durivault J, Vial V, Bayer P, Noleto G, Mazure N, Zdralevic M, Pouyssegur J
Oncotarget 8(50): 87623-87637 -
Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells
Parks S, Cormerais Y, Durivault J, Pouyssegur J
Oncotarget 8(6): 10225-10237 -
Targeting the pro-angiogenic forms of VEGF or inhibiting their expression as anti-cancer strategies
Guyot M, Hilmi C, Ambrosetti D, Merlano M, Lo Nigro C, Durivault J, Grépin R, Pagès G
Oncotarget 8(6): 9174-9188 -
Genetic disruption of the multifunctional CD98/LAT1 complex demonstrates the key role of essential amino acid transport in the control of mTORC1 and tumor growth
Cormerais Y, Giuliano S, Le Floch R, Front B, Durivault J, Tambutté E, Massar P-A, Rodriguez de la Ballina L, Endou H, Wempe M F, Palacin M, Parks S, Pouyssegur J
Cancer Res 76(15): 4481-4492